Studies of treatment with ipilimumab, alone or in combination with anti-PD-1 or high-dose interleukin (IL)-2, have reported response rates of around 25–30% in patients who failed on anti-PD-1 treatment, which represent the current benchmark for new treatment strategies in this population. Patients with advanced melanoma who progress after anti-PD-1 inhibitor therapy have limited treatment options. Khushalani: in favour of adoptive cell therapy Audiences voted both before and after each debate. As with previous Bridge congresses, the debates were assigned by meeting Chairs and positions taken by experts during the debates may not have necessarily reflected their respective personal view. The debates considered the use of adoptive cell therapy versus use of bispecific antibodies to treat melanoma, MAPK inhibitors versus immunotherapy in the adjuvant setting, whether the use of corticosteroids for the management of immune-related side effects has an impact on outcomes, the choice of cytotoxic T lymphocyte-associated antigen (CTLA)-4 or lymphocyte-activation gene (LAG)-3 inhibitor as the best option to combine with anti-programmed-death (PD)-1 therapy, whether radiation is needed for brain metastases, whether lymphadenectomy is best done before adjuvant therapy or later and telemedicine versus face-to-face visits. The Great Debate session at the 2021 Melanoma Bridge virtual congress (December 2–4) featured counterpoint views from experts on seven important issues in melanoma. The debates considered the use of adoptive cell therapy versus use of bispecific antibodies, mitogen-activated protein kinase (MAPK) inhibitors versus immunotherapy in the adjuvant setting, whether the use of corticosteroids for the management of side effects have an impact on outcomes, the choice of programmed death (PD)-1 combination therapy with cytotoxic T-lymphocyte-associated antigen (CTLA)-4 or lymphocyte-activation gene (LAG)-3, whether radiation is needed for brain metastases, when lymphadenectomy should be integrated into the treatment plan and then the last debate, telemedicine versus face-to-face.
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